منابع مشابه
The essence of SNPs.
Single nucleotide polymorphisms (SNPs) are an abundant form of genome variation, distinguished from rare variations by a requirement for the least abundant allele to have a frequency of 1% or more. A wide range of genetics disciplines stand to benefit greatly from the study and use of SNPs. The recent surge of interest in SNPs stems from, and continues to depend upon, the merging and coincident...
متن کاملSPOT: a web-based tool for using biological databases to prioritize SNPs after a genome-wide association study
SPOT (http://spot.cgsmd.isi.edu), the SNP prioritization online tool, is a web site for integrating biological databases into the prioritization of single nucleotide polymorphisms (SNPs) for further study after a genome-wide association study (GWAS). Typically, the next step after a GWAS is to genotype the top signals in an independent replication sample. Investigators will often incorporate in...
متن کاملGenome-Wide Analysis of Tar Spot Complex Resistance in Maize Using Genotyping-by-Sequencing SNPs and Whole-Genome Prediction.
Tar spot complex (TSC) is one of the most destructive foliar diseases of maize ( L.) in tropical and subtropical areas of Central and South America, causing significant grain yield losses when weather conditions are conducive. To dissect the genetic architecture of TSC resistance in maize, association mapping, in conjunction with linkage mapping, was conducted on an association-mapping panel an...
متن کاملXNA marks the spot
The new field of synthetic genetics has made significant advances during the past four years, both to create artificial and modified nucleic acids, and to investigate their structural and functional properties. This rapid progress promises to improve our understanding of the origins and fundamental basis of life, and to enhance the application of this knowledge in the search for new therapeutic...
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ژورنال
عنوان ژورنال: Nature Reviews Genetics
سال: 2003
ISSN: 1471-0056,1471-0064
DOI: 10.1038/nrg1119